The NFL is back. Preseason is wrapped, the talking is over, and our NFL Week 1 predictions and tips are live. We’ve a cracking 12/1 accumulator (parlay, for our friends across the pond) that looks super-strong in terms of value, as we run the numbers for the opening weekend.
In true NFL style, we’re two games in and already the form book has been ripped up. The Eagles kicked us off on Thursday night as they started their title defence on the road against the Dallas Cowboys.
It wasn’t the blowout that many had predicted, as they scraped to a 24-20 win, with just a single field goal (Eagles) scored by both teams in the second half.
But the biggest shock came at Arrowhead Stadium, where the Chiefs lost 27-21 to the Chargers. Justin Herbert went 25-34, threw for 318 yards, and completed three TDs to cause a massive upset by beating last year's Super Bowl runners-up. We are so back.
We've got some huge games coming up on Sunday, along with a value-packed accumulator to sink your teeth into as part of our NFL Week 1 predictions and tips.
NFL Week 1 Predictions – Game Lines Acca – £10 Pays £136.19 (inc. Boost)
Our NFL Week 1 predictions include a tasty-looking four-fold, paying £136.19 at bet365, one of our top-rated NFL betting sites. This comes with a 5% boost as part of their NFL acca boost promo, where you can get up to 100% on your NFL acca bets.
| Game | Market | Odds |
|---|---|---|
| Tampa Bay Buccaneers @ Atlanta Falcons | TB Buccaneers – Moneyline | 20/23 |
| San Francisco 49ers @ Seattle Seahawks | Over 43.5 – Game Totals | 10/11 |
| Miami Dolphins @ Indianapolis Colts | Miami +1 – Point Spread | 20/23 |
| Tennessee Titans @ Denver Broncos | Denver -8.5 – Points Spread | 10/11 |
*Odds correct as of 10:00 BST on 06/09/2025. Odds subject to change.
No Expiry Date
Bet 1: Tampa Bay Buccaneers Moneyline – 20/23
This is a classic case of the market shading home-field advantage for the Falcons and their head-to-head sweep last season. The Bucs were by far the better team, eventually winning the NFC South Championship, with a top-five offence, averaging 29.5 points per game (PPG). Compare that to the Falcons having a bottom-ten defence (allowing 24.9 PPG) and we’ve got a mismatch here.
A late-season collapse by the Falcons, losing six of their last eight games, is alarming. Kirk Cousins was eventually benched, and while they’ve plugged some of those gaps, a lot rests on the rookie, Michael Penix Jr., which, as we know, is a lot to ask in a first season. Kaleb McGary, missing at offensive tackle, was the final nail in the coffin, suggesting that the Bucs on the moneyline is the play.
Bet 2: 49ers @ Seahawks Over 43.5 Total – 10/11
A line of 43.5 for the over in the game totals is too good to turn down for San Fransico visiting Seattle. Just from last season's numbers alone, the 49ers averaged 22.2 PPG and the Seahawks 22.1 PPG, already getting us over the line for a market we’d set around 45.5, so there’s value in this alone at 10/11.
Divisional games like this can be spiky, but they cruised the over in last year's game, which finished 36-24 (60). If we open that window ever so slightly, the 49ers are an 11-8-1 team for the overs spread. Both teams hover around the league average for scoring, but the mean projection is clearly over 43.5, and recent history shows that this is another solid pick, even though reasonably priced by the best betting sites in terms of value.
Bet 3: Dolphins +1.0 @ Colts – 20/23
This might be a tough watch in Indianapolis. Neither team will pull up trees this season, and they both struggled for large parts of 2024. Miami is getting the nod, but it’s more to do with the desperate state of the Colts than any divine intervention from Mike McDaniel. Heading into the game with Daniel Jones as a starter tells you all you need to know, with more interceptions (13) than touchdowns (10) to his name.
The Dolphins will continue to run with Tua, Tyreek Hill, and Jaylen Waddle, a squad that had so much promise when first formed three seasons ago. But injuries and off-field dramas have plagued the trio, and the Dolphins have struggled for stability as a result.
Firing Defensive Coordinator Gus Bradley was always on the cards this summer for the Colts, but it takes time to bed in a new system, and Week 1 likely won’t yield results for one of the worst defensive rush teams in the league – the Dolphins +1.0 to cover and then some is the play.
Bet 4: Broncos -8.5 vs Titans – 10/11
Talk about out of the frying pan and into the fire for the Titans' new first-round NFL draft pick quarterback, Cam Ward. He kicks off his NFL career against the league's most formidable defence in the Broncos, who lead in defensive pass rushes, Red Zone TD allowance, and passing defence. Oh, and of course, sacks. Welcome to the big leagues, Cam.
The Broncos covered the spread in 13 of their last 20 games, while the Titans slumped to 3-14. Denver went on a tear towards the end of last season, with huge wins against the Falcons, Colts and Chiefs, so they’re no strangers to laying down big numbers.
It’s the biggest spread of the weekend, but with a rookie QB, the Broncos retaining 61.5 of their 63 sacks in terms of defensive linemen, and a team not afraid of posting big scores, this ticks the boxes for the final part of our NFL Week 1 predictions and tips.
