The league phase of the Champions League is underway and arguably the standout tie of Matchday 1 takes place at Anfield where Liverpool host Atlético Madrid. And we have come up with a great value bet builder at bet365 where a £10 wager will bring you a return of £130.
Champions League 2025/26: Liverpool vs Atlético Madrid Odds
After an outstanding first season which saw him land the Premier League title Arne Slot has splashed the cash this summer with a serious assault on the Champions League very much on the agenda.
Atléti will, however, be a tough nut to crack, despite travelling to Anfield with a number of injury problems. Diego Simeone has given Atlético arguably the longest spell of success in their history since he arrived in 2011 and they are consistently genuine contenders domestically and in Europe.
The bookies make Liverpool favourites. Here are the odds from bet365, one of the UK’s leading football betting sites.
| Liverpool Win | Draw | Atlético Madrid Win |
|---|---|---|
| 1/2 | 10/3 | 5/1 |
Odds correct on 17/09/2025 at 10:45. Odds subject to change.
Champions League 2025/26 Liverpool vs Atlético Madrid Bet Builder
Our experts have found four fantastic wagers to put into a bet builder for the match. A £10 bet with bet365 will see you get a £130 payout if all four bets come in. Furthermore, you can apply the bookie’s winnings boost promo which means you would land £166.
| Market | Pick | Odds from bet365 |
|---|---|---|
| Total Goals | Under 2.5 Goals | 13/10 |
| Total Cards | Over 3.5 | 4/6 |
| Total Corners | Over 10 | 5/4 |
| Player shots on target | Alexander Isak over 0.5 | 1/2 |
| Bet builder: 12/1 |
Odds correct on 17/09/2025 at 10:45. Odds subject to change.
Now let’s have a look at our four picks in detail.
Bet 1: Under 2.5 goals (13/10)
Despite the attacking talent on display we are expecting a tight game here. Liverpool scored four against Bournemouth and three against Newcastle United, however, conceded twice in each game. They have tightened up defensively since then, but this has come at an expense.
The home match against fellow title contenders Arsenal was attritional and it took a brilliant free kick from Dominik Szoboszlai to break the deadlock. They were then held until injury time against newly promoted Burnley until a Mo Salah penalty gave them the three points.
Simeone has built his strategy on a solid defence and it has served him and Atlético Madrid well. During his tenure they have kept clean sheets in over 40% of their Champions League matches. With several players doubtful and former Manchester City forward Julien Alvarez ruled out there is even more reason to suspect that Los Rojiblancos will travel to Merseyside with the intention of keeping things tight. We are confident that this match will feature two goals or less.
Bet 2: Over 3.5 Cards (4/6)
It is a gross understatement to say that being difficult to play against is a trait of Simeone’s Atléti. A consequence of this can be frequent bookings. Furthermore, both sides have racked up eight cards in their four league matches to date.
Atléti are likely to come with the intention of quietening the crowd and disrupting the rhythm of the game. When you do this, you risk cards. These tactics could also frustrate Liverpool which may make them more likely to pick up bookings. We have every reason to believe that there will be four cards or more in this one.
Bet 3: Over 10 Corners (5/4)
Looking at the Premier League and La Liga statistics on our stats hub you can see that Liverpool and Atlético Madrid have won 23 and 27 corners respectively in their four league matches. We think that there is a strong possibility of double figures in this one.
Bet 4: Alexander Isak Over 0.5 Shots on Target (1/2)
Alexander Isak could make his Liverpool debut in this one. The Swede is struggling for match fitness after training alone ahead of his move from Newcastle United and was not deemed fit enough to make the squad against Burnley at the weekend. And according to the Daily Mirror Slot has hinted that Isak could be involved against Atlético.
We don’t think that the former Newcastle striker will be firing on all cylinders, and we don’t think that he will be on from the start. However, he will want to make an impression, and we think he will at least register a shot or two on target. Last season he averaged 1.34 shots on target per game in the Premier League, the division's fourth highest. We’re not ready to back him to score but we think he’ll work the goalkeeper at some point.
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